Bijspuitschema in de ban (2025)

Abstract

Hyperglycemia at admission is associated with complications and mortality. There is only little evidence, however, for beneficial effects of strict glycemic control during hospitalization. Strict glycemic control may prevent postoperative infections. Strict control can increase the risk of hypoglycemia, which is independently associated with mortality. The ideal glucose target values for patients admitted to a general ward range from 5.6 to 10 mmol/L, with consideration for higher targets in certain populations. The sliding scale insulin regimen stands as a hallmark prescription for medical interns in hospital settings, yet the evidence shows this regimen is ineffective. Guidelines have been advising against the sliding scale regimen for almost 20 years. We advocate a basal-bolus insulin regimen for the management of elevated glucose levels, while tolerating mild hyperglycemia.A transition away from sliding insulin towards basal-bolus insulin, has shown promising outcomes. Embracing a paradigm shift towards basal-bolus insulin regimens offers a more nuanced approach to glucose management, leading to better patient outcomes and a lower workload for healthcare providers.

Original languageDutch
JournalNederlands tijdschrift voor geneeskunde
Volume168
Publication statusPublished - 3 Dec 2024

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Apperloo, E. M., Hermanides, J., & Vriesendorp, T. M. (2024). Bijspuitschema in de ban. Nederlands tijdschrift voor geneeskunde, 168.

Apperloo, E. M. ; Hermanides, J. ; Vriesendorp, T. M. / Bijspuitschema in de ban. In: Nederlands tijdschrift voor geneeskunde. 2024 ; Vol. 168.

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title = "Bijspuitschema in de ban",

abstract = "Hyperglycemia at admission is associated with complications and mortality. There is only little evidence, however, for beneficial effects of strict glycemic control during hospitalization. Strict glycemic control may prevent postoperative infections. Strict control can increase the risk of hypoglycemia, which is independently associated with mortality. The ideal glucose target values for patients admitted to a general ward range from 5.6 to 10 mmol/L, with consideration for higher targets in certain populations. The sliding scale insulin regimen stands as a hallmark prescription for medical interns in hospital settings, yet the evidence shows this regimen is ineffective. Guidelines have been advising against the sliding scale regimen for almost 20 years. We advocate a basal-bolus insulin regimen for the management of elevated glucose levels, while tolerating mild hyperglycemia.A transition away from sliding insulin towards basal-bolus insulin, has shown promising outcomes. Embracing a paradigm shift towards basal-bolus insulin regimens offers a more nuanced approach to glucose management, leading to better patient outcomes and a lower workload for healthcare providers.",

author = "Apperloo, {E. M.} and J. Hermanides and Vriesendorp, {T. M.}",

year = "2024",

month = dec,

day = "3",

language = "Dutch",

volume = "168",

journal = "Nederlands tijdschrift voor geneeskunde",

issn = "0028-2162",

publisher = "Bohn Stafleu Van Loghum",

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Apperloo, EM, Hermanides, J & Vriesendorp, TM 2024, 'Bijspuitschema in de ban', Nederlands tijdschrift voor geneeskunde, vol. 168.

Bijspuitschema in de ban. / Apperloo, E. M.; Hermanides, J.; Vriesendorp, T. M.
In: Nederlands tijdschrift voor geneeskunde, Vol. 168, 03.12.2024.

Research output: Contribution to journalReview articleProfessional

TY - JOUR

T1 - Bijspuitschema in de ban

AU - Apperloo, E. M.

AU - Hermanides, J.

AU - Vriesendorp, T. M.

PY - 2024/12/3

Y1 - 2024/12/3

N2 - Hyperglycemia at admission is associated with complications and mortality. There is only little evidence, however, for beneficial effects of strict glycemic control during hospitalization. Strict glycemic control may prevent postoperative infections. Strict control can increase the risk of hypoglycemia, which is independently associated with mortality. The ideal glucose target values for patients admitted to a general ward range from 5.6 to 10 mmol/L, with consideration for higher targets in certain populations. The sliding scale insulin regimen stands as a hallmark prescription for medical interns in hospital settings, yet the evidence shows this regimen is ineffective. Guidelines have been advising against the sliding scale regimen for almost 20 years. We advocate a basal-bolus insulin regimen for the management of elevated glucose levels, while tolerating mild hyperglycemia.A transition away from sliding insulin towards basal-bolus insulin, has shown promising outcomes. Embracing a paradigm shift towards basal-bolus insulin regimens offers a more nuanced approach to glucose management, leading to better patient outcomes and a lower workload for healthcare providers.

AB - Hyperglycemia at admission is associated with complications and mortality. There is only little evidence, however, for beneficial effects of strict glycemic control during hospitalization. Strict glycemic control may prevent postoperative infections. Strict control can increase the risk of hypoglycemia, which is independently associated with mortality. The ideal glucose target values for patients admitted to a general ward range from 5.6 to 10 mmol/L, with consideration for higher targets in certain populations. The sliding scale insulin regimen stands as a hallmark prescription for medical interns in hospital settings, yet the evidence shows this regimen is ineffective. Guidelines have been advising against the sliding scale regimen for almost 20 years. We advocate a basal-bolus insulin regimen for the management of elevated glucose levels, while tolerating mild hyperglycemia.A transition away from sliding insulin towards basal-bolus insulin, has shown promising outcomes. Embracing a paradigm shift towards basal-bolus insulin regimens offers a more nuanced approach to glucose management, leading to better patient outcomes and a lower workload for healthcare providers.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85211040653&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/39606867

M3 - Review article

C2 - 39606867

SN - 0028-2162

VL - 168

JO - Nederlands tijdschrift voor geneeskunde

JF - Nederlands tijdschrift voor geneeskunde

ER -

Apperloo EM, Hermanides J, Vriesendorp TM. Bijspuitschema in de ban. Nederlands tijdschrift voor geneeskunde. 2024 Dec 3;168.

Bijspuitschema in de ban (2025)
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